A 2-Gene Host Signature for Improved Accuracy of COVID-19 Diagnosis Agnostic to Viral VariantsArticle Published on 2023-02-232023-07-11 Journal: mSystems [Category] COVID19(2023년), [키워드] Classifier COVID-19 diagnostics Gene Expression metagenomics transcriptomics. [DOI] 10.1128/msystems.00671-22 PMC 바로가기
Molecular modeling of C1-inhibitor as SARS-CoV-2 target identified from the immune signatures of multiple tissues: An integrated bioinformatics studyArticle Published on 2023-01-012023-07-11 Journal: Cell biochemistry and function [Category] COVID19(2023년), [키워드] C1-Inhibitor COVID-19 druggability assessment Explainable artificial intelligence Gene Expression immune-related genes Machine learning. SHapley Additive exPlanations [DOI] 10.1002/cbf.3769 PMC 바로가기
Selection of Ideal Reference Genes for Gene Expression Analysis in COVID-19 and MucormycosisArticle Published on 2022-12-212023-07-10 Journal: Microbiology Spectrum [Category] COVID19(2023년), [키워드] COVID-19 CypA Gene Expression IL-6 Mucormycosis Nrf2 qRT-PCR reference gene. SARS-CoV-2 [DOI] 10.1128/spectrum.01656-22 PMC 바로가기
Transcriptomic analysis of the innate immune signatures of a SARS-CoV-2 protein subunit vaccine ZF2001 and an mRNA vaccine RRVSARS-CoV-2 단백질 소단위 백신 ZF2001 및 mRNA 백신 RRV의 타고난 면역 특징의 전사체 분석Article Published on 2022-12-012022-09-11 Journal: Emerging Microbes & Infections [Category] COVID19(2023년), SARS, 유전자 메커니즘, 진단, [키워드] Activation Analysis Anti-viral antibody approach binding CD74 Cell comparable COVID-19 cytokine Cytokines early response elicited expression level expression of gene framework Gene Expression Genes immune response immune responses immunization innate immune innate immune response Innate immunity involved mapped MHC class mRNA mRNA vaccine neutralization Neutralization antibody Pattern recognition pattern recognition receptor Pattern recognition receptors post vaccination Protein subunit protein subunit vaccine PRRs RNA degradation robust SARS-CoV-2 SARS-CoV-2 protein subunit Subunit vaccine Tap1 titre titres Transcription transcriptional Transcriptome transcriptome sequencing Transcriptome sequencing. transcriptomic transduction Vaccine ZF2001 [DOI] 10.1080/22221751.2022.2059404 PMC 바로가기 [Article Type] Article
Environmental pathways affecting gene expression (E.PAGE) as an R package to predict gene-environment associationsArticle Published on 2022-11-042022-11-16 Journal: Scientific Reports [Category] 유전자 메커니즘, [키워드] Abstract affecting articles association biological processe Cell comprehensive resource COVID-19 criteria curated database dataset develop diabetes differentially expressed gene dysregulated enriched biological processes environmental factor environmental factors Gene Expression Gene Expression Omnibus Genes Infection initial Interaction lung cancer pathway predict R package retrieved rheumatoid arthritis selected signature smoking statistical analysis statistically tested [DOI] 10.1038/s41598-022-21988-6 PMC 바로가기
More tools for our toolkit: The application of HEL-299 cells and dsRNA-nanoparticles to study human coronaviruses in vitroArticle Published on 2022-11-012022-11-15 Journal: Virus research [Category] SARS, 치료법, 치료제, [키워드] ACE2 receptor Analysis Antiviral antiviral genes antiviral response antiviral therapy can be used Cell cell line cells Combination competent Complete coronavirus Coronavirus replication CXCL10 cytidylic acid double-stranded expand fibroblast Gene Expression HCoV-229E HCoV-NL63 help Human human coronavirus human coronaviruses human lung IFN IFNs IFNβ in vitro increase in inducer Infection inhibit innate immune interferons ISG15 limit MERS-CoV Nanoparticles Pathogens Poly I:C. post infection PROTECT provided required SARS-CoV-2 SARS-CoV-2 pandemic stimulate translated Treatment Type I IFN type I interferon virus production were infected while [DOI] 10.1016/j.virusres.2022.198925 PMC 바로가기
Host gene expression is associated with viral shedding magnitude in blue-winged teals (Spatula discors) infected with low-path avian influenza virusArticle Published on 2022-11-012023-06-22 Journal: Comparative Immunology, Microbiology and Infectious Diseases [Category] 조류인플루엔자, [키워드] Avian Influenza blue-winged teal Gene Expression RNA-Seq Supershedders Viral shedding. [DOI] 10.1016/j.cimid.2022.101909 PMC 바로가기
Smoking modulates different secretory subpopulations expressing SARS-CoV-2 entry genes in the nasal and bronchial airwaysArticle Published on 2022-10-282022-11-16 Journal: Scientific Reports [Category] COVID19(2023년), SARS, 치료기술, [키워드] ACE2 airway airway epithelium airways association C15orf48 cell population changes in characterized club co-expressed cohorts CTSL diagnostic workup disease severity elevated epithelial cells expressed expressing expression expression data Gene Expression gene expression pattern Goblet cell increase in indicated individual Infection lung cancer lung cancer risk modulate modulated nasal Population SARS-CoV-2 SARS-CoV-2 entry SARS-COV-2 infection scRNA-seq secretory cell severe disease significantly similarity smoker smoking smoking status subpopulation TMPRSS2 viral entry Viral load [DOI] 10.1038/s41598-022-17832-6 PMC 바로가기
Interaction of HDAC2 with SARS-CoV-2 NSP5 and IRF3 Is Not Required for NSP5-Mediated Inhibition of Type I Interferon Signaling PathwayArticle Published on 2022-10-262022-11-15 Journal: Microbiology Spectrum [Category] COVID19(2023년), SARS, 치료제, [키워드] abrogate activated addition bind binding biological significance cellular processe complex disrupt DNA Epigenetic Evidence expression favor Gene Expression HDAC2 Host host antiviral response IFN response IFN signaling pathway IFN-stimulated genes IFNβ IL-1β IL-6 immune response gene inhibit inhibition inhibitory interact Interaction interferons involved IRF3 nsp5 over Pathogenesis pathway promote promoter promoters protease Protease activity protein interaction protein-protein interactions reduce Regulation Replication repress required RNA SARS-CoV-2 SARS-CoV-2 protein Signaling signaling pathway significantly subset Type Type I IFN type I IFN signaling. type I interferon viral infection viral infections Viral protein virus [DOI] 10.1128/spectrum.02322-22 PMC 바로가기
SARS-CoV-2 Diverges from Other Betacoronaviruses in Only Partially Activating the IRE1α/XBP1 Endoplasmic Reticulum Stress Pathway in Human Lung-Derived CellsArticle Published on 2022-10-262022-11-15 Journal: mBio [Category] COVID19(2023년), SARS, 유전자 메커니즘, 진단, 치료기술, [키워드] activate Activation activities activity acute respiratory syndrome betacoronaviruses Cell cellular change coronavirus coronavirus country Critical death downstream Endoplasmic reticulum enzyme ER stress examined expression of gene functions Gene Expression HCoV-OC43 Host host cell host cells host immune system Human human cell human cells imperative individual induce infect Infection inhibit interact IRE1α pathway less limit MERS-CoV MHV Middle East molecular mechanism mRNA murine OC43 Other other coronavirus pathway Prevent processed Replication required Respiratory Coronavirus respiratory syndrome coronavirus Reticulum RNase SARS-CoV SARS-CoV-2 SARS-COV-2 infection severe respiratory disease signaling pathway similarity splice Spread Stress tested the interferon transcription factor Trigger unfolded protein response Unfolded protein response. UPR Vaccine viral replication virus XBP1 [DOI] 10.1128/mbio.02415-22 PMC 바로가기